Tissue paper is often made with a variety of chemicals, including dyes, heavy metals, and phthalates. Some of the most commonly used dyes are triarylmethane (TAM) dyes or quinoline yellow which can be harmful to your health if ingested. Heavy metals such as lead and mercury are also present in tissue paper and may induce negative effects like brain damage or cancer. Phthalates are organic compounds that act as plasticizers, Hardeners agents for polymers, etc. They can cause reproductive problems in both men and women by disrupting the hormones system.